Monday, November 26, 2012

Can Genome-Wide Association Studies (GWAS) Solve Complex Diseases?

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       The field of Human Genetics has developed as the study of Mendelian-monogenic diseases. Their identification  not only enables diagn...
Tuesday, May 15, 2012

Personalized Cancer Medicine: Individual Patient Therapy through Next-Gen Sequencing

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On Dancey et al., 2012 in Cell and  On Roychowdhury et al.,2011 in Sci Transl Med Human Cancer is a complex, multi-factorial and het...
Wednesday, March 7, 2012

Clonal Evolution of a Tumor in Two Separate Hosts

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On Weigert et al., 2012  in Cancer Discovery Follicular lymphoma is the tumor of Follicle Center B-cells. Although Bcl2-IGH rearrangement...
Wednesday, February 22, 2012

An Epigenetic Factor Directs Meiotic Recombination

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Image Courtesy of Science Photo Library  C009/9397 On Grey et al., 2011 in PLoS Biology Although the principles of inheritance as describ...
Sunday, January 22, 2012

Stable (Heritable) DNA Transfer without Antibiotic Selection?

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On Mendiburo et al., 2011 in Science      Centromeres are the chromatin regions that are specialized to carry out the chromosome segre...
Saturday, January 7, 2012

Long Non-Coding RNAs

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On  Ørom and Shiekhattar, 2011 in  Curr Opin Genet Dev Approximately 1.5 % of our genome is transcribed to protein-coding mRNA.  The exi...
Sunday, December 18, 2011

Unstated Rules of the Academia

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" What they didn't teach you in Grad School " by Paul Gray and David E Drew  is a valuable book for anyone considering a...